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What is celiac disease?

Wat is coeliakie?

Celiac disease is an autoimmune disease characterized by an intolerance to gluten, a protein found in wheat, barley and rye. When someone with celiac disease consumes gluten, their immune system responds by damaging the villi in the small intestine. This can lead to a wide range of symptoms and health problems.

What is celiac disease?

Celiac disease is a chronic autoimmune disease characterized by an intolerance to gluten. When someone with celiac disease consumes gluten, their immune system responds by damaging the villi in the small intestine. These intestinal villi are responsible for the absorption of nutrients from our food. When they are damaged, they cannot do their job properly, which can lead to malnutrition and other health problems.

Symptoms of celiac disease

The symptoms of celiac disease can vary greatly from person to person. Some people experience severe symptoms, while others have no symptoms at all. The most common symptoms include abdominal pain, bloating, diarrhea, weight loss, fatigue and anemia. In some cases, celiac disease can also lead to problems with the skin, nervous system and fertility.

Diagnosis of celiac disease

Celiac disease can be diagnosed by a blood test and an endoscopy of the small intestine. The blood test looks for antibodies typical of celiac disease. If the blood test is positive, an endoscopy is performed to look at the intestinal villi in the small intestine. If these are damaged, this confirms the diagnosis of celiac disease.

Treatment of celiac disease

The only effective treatment for celiac disease is a strict gluten-free diet. This means that all foods and drinks containing gluten should be avoided. This can be challenging because gluten is found in many different foods, including bread, pasta, cookies and many processed foods. Research shows that people who follow a gluten-free diet unknowingly or unintentionally consume between 200 and 3,000 mg of gluten per day. [1]

Celiac disease and gluten sensitivity

It is important to understand that celiac disease is different from gluten sensitivity. While people with celiac disease have an autoimmune reaction to gluten, people with gluten sensitivity have no damage to their intestines. Instead, they experience symptoms such as bloating, stomach pain and fatigue after eating gluten. Although strict avoidance of gluten can also alleviate their symptoms, it is usually not necessary for them to avoid gluten completely, as is the case with celiac disease.

Living with celiac disease

Although living with celiac disease can be challenging, it is possible to live a healthy and fulfilling life with the right treatment and support. Maintaining a strict gluten-free diet is essential. In addition, regular medical follow-up can help in the management of the disease and early detection of any complications. It's also helpful to connect with other people living with celiac disease, whether that's online, in support groups, or through celiac disease organizations. They can provide helpful tips and advice, as well as emotional support.


Celiac disease is a serious autoimmune disease that can cause serious damage to the small intestine when ingesting gluten. Maintaining a strict gluten-free diet is key to managing celiac disease and preventing further health problems. With the right diagnosis, treatment and support, people with celiac disease can live full, healthy and fulfilling lives.


F. van Overbeek et al. 'The daily gluten intake in relatives of patients with celiac disease compared with that of the general Dutch population', Eur J Gastroenterol Hepatol, 1997, vol. 9, no. 11, p1097-9

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What is Tolerase® G?

What is Tolerase® G?

A New Approach for People with Gluten Sensitivity: Explore the Science and Benefits of Tolerase® G.

Relief from Gluten Sensitivity

In the fight against gluten, there is a unique supplement that stands out: the anti-gluten pills from Little Helpers with 100% Tolerase® G.

This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1 ) ​. Additionally, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten's toxicity ( 2 ) ( ​​3 ) ​.

On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What are Gluten?

Gluten is a group of proteins found primarily in grains such as wheat, barley and rye. These complex proteins give shape, strength and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why approximately 13% of the world's population is sensitive to gluten in the diet (1)​.

The Effect of Tolerase® G

It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).

Studies have shown that a newly identified prolyl endoprotease, derived from Aspergillus niger, can effectively break down gluten proteins. This enzyme works optimally at a pH of 4-5, remains stable at a pH of 2 and is completely resistant to digestion with pepsin ( 2 ). Additionally, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that hardly any gluten reaches the duodenum ( 3 ). This implies that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity. This gives people the opportunity to (occasionally) give up their strict gluten-free diet ( 3 ).

Unique Enzyme Solution

Discover how our pills with 100% Tolerase® G help with the digestion of gluten and support your lifestyle in a clear video.

Little Helpers & Tolerase® G: Stronger Together in the Fight Against Gluten.

At Little Helpers we are proud of our unique collaboration with the manufacturer of Tolerase® G DSM . Together we have spent 2.5 years researching and working tirelessly on the development and perfection of our gluten digestion pill, which contains 100% Tolerase® G.

Our shared commitment to quality and effectiveness has resulted in a product that is unrivaled on the market. We have chosen to produce locally in Europe to ensure the highest quality standards and control.

Our pill has proven to be many times more effective than those of our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That's why we encourage everyone to try it and experience the benefits for themselves!

Superior gluten degradation

Tolerase® G is many times more effective than any other supplement available and is the only enzyme scientifically proven to be effective enough to break down gluten to the point that the body no longer responds to it.